Doravirine▼ Real World Data

DELSTRIGO®▼ (doravirine/3TC/TDF)
Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland) [External links]
PIFELTRO®▼ (doravirine)
Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland) [External links]

Doravirine/3TC/TDF = DELSTRIGO (doravirine/lamivudine/tenofovir disoproxil fumarate).

PIFELTRO®▼ (doravirine) 100 mg film-coated tablet is indicated, in combination with other antiretroviral medicinal products, for the treatment of adults, and adolescents aged 12 years and older, weighing at least 35 kg, infected with HIV-1, without past or present evidence of resistance to the NNRTI class.

DELSTRIGO®▼ (100 mg doravirine/300 mg lamivudine/300 mg tenofovir disoproxil fumarate, equivalent to 245 mg tenofovir disoproxil) is indicated for the treatment of adults infected with HIV-1 without past or present evidence of resistance to the NNRTI class, lamivudine or tenofovir.

DELSTRIGO®▼ is also indicated for the treatment of adolescents aged 12 years and older weighing at least 35 kg, who are infected with HIV-1, without past or present evidence of resistance to the NNRTI class, lamivudine, or tenofovir and who have experienced toxicities which preclude the use of other regimens that do not contain tenofovir disoproxil.

Please consult the SmPC for further information before making any prescribing decisions.

Real World Data: Switching to doravirine in ART-experienced people with HIV

This is an animated video (length 05:21) of a real-world study conducted in the Netherlands (published 1 February 2024) .

In this retrospective cohort study, participants switched to a doravirine containing ART regimen, and its efficacy and tolerability was evaluated one year after the switch.

Filming fully organised and funded by MSD.

DELSTRIGO®▼ (doravirine/3TC/TDF) Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland) [External links]
PIFELTRO®▼ (doravirine) Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland) [External links]

Length: 05:21

Abbreviations included in video

ALT = Alanine Aminotransferase; ART = Antiretroviral Therapy; ATV/r/FTC/TDF = atazanavir/ritonavir/emtricitabine/tenofovir disoproxil fumarate; BIC/FTC/TAF = bictegravir/emtricitabine/tenofovir alafenamide; BMI = Body Mass Index; CD4 = T-Lymphocyte; DOL/FTC/TDF = dolutegravir/emtricitabine/tenofovir disoproxil fumarate; DOL/3TC/ABC = dolutegravir/lamivudine/abacavir; DOR/3TC/TDF = doravirine/lamivudine/tenofovir disoproxil fumarate; DRV/r/FTC/TDF = darunavir/ritonavir/emtricitabine/tenofovir disoproxil fumarate; EFV/FTC/TDF = efavirenz/emtricitabine/tenofovir disoproxil fumarate; eGFR = Estimated Glomerular Filtration Rate; EVG/c/FTC/TAF = elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide; EVG/c/FTC/TDF = elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate; HDL = high-density Lipoprotein; INSTIs = Integrase Strand Transfer Inhibitors; IQR = interquartile range; LDL = low-density Lipoprotein; NNRTI = Non-Nucleoside Reverse Transcriptase Inhibitor; OLVG = Onze Lieve Vrouwe Gasthius (English: ‘Our Lady Hospital’); PI = Protease inhibitor; RPV/FTC/TAF = rilpivirine/emtricitabine/tenofovir alafenamide; RPV/FTC/TDF = rilpivirine/emtricitabine/tenofovir disoproxil fumarate; SD = standard deviation; U/L = units per litre; TDF = tenofovir disoproxil fumarate.

Reference

Lanting VR et al. Switching to Doravirine in cART-Experienced Patients: An Effective and Highly Tolerated Option With Substantial Cost Savings, J Acquir Immune Defic Syndr. 2024;95:190–196.

Supporting documentation

DELSTRIGO®▼ Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland)
PIFELTRO®▼ Prescribing Information (Great Britain) & Prescribing Information (Northern Ireland)
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